In seeing exactly how an athlete might and might not benefit from Cytadren, we can look at studies demonstrating that the main mechanism in which Cytadren benefits breast cancer patients (inhibition of peripheral aromatase activity) is different from that which interferes with corticosteroid production We also see that the dosage of Cytadren is important in triggering each particular response. It appears that aromatase inhibition is achieved at a much lower dose than is needed to block steroid production by the adrenal gland. While a daily Cytadren dosage of 1000mg is typically needed to inhibit the demolase enzyme (the enzyme responsible for converting cholesterol to pregnenolone, and the target when reduced adrenal output is needed), maximum suppression of aromatase and estrogen levels is achieved at a dosage between 250 and 500mg (a point where adrenal steroid blockage should not be noted). There also seems to be no added benefit by adding cortisol in terms of survival/response rate among breast cancer patients, pointing to the fact that the "adrenal escape phenomenon" bears no relation at all to its abilities as an aromatase inhibitor. We find that not only do we need a very high dose (4 tablets per day) to really inhibit cortisol production, but also that there is no need for an athlete to implement a rotating dose schedule if the drug is being used as an anti-estrogen.
Estrogenic side effect of Cytadren
In effectiveness as an estrogen maintenance agent this compound rates highly. Studies have shown it capable of decreasing aromatase activity as much as 92% after administration of only 250mg, and patient response rates show amin to be at least as effective as tamoxifen therapy in treating estrogen dependent c cells, more under certain conditions. However, due to its discussed broad range of activity, includin potential inhibition of not only estrogens, but corticosteroids, aldosterone and androgens as well, it is not regs as highly in terms of patient comfort. This is not to give the impression that complaints are very common the as aminoglutethimide still has an extremely good safety record. It has simply been pushed aside in many case more recently developed and selective agents. Athletes can however still consider it to be an extremely effe remedy for estrogenic side effects should it be available on the black market, at least as much so as Nolvadex for the daily dosage when taking Cytadren to minimize estrogenic side effects, most experiment with anyw from 1/2 a tablet to 2 tablets per day, with one tablet of 250mg probably being the most common dosage select.
Some kind information about Cytadren
Cytadren is an expensive pharmaceutical, selling for approximately $2 per tablet on the black market. This is probably the reason Cytadren's use has not become more widespread. This price of Cytadren is however still considerably less than what would be spent on the more recently developed antiaromatase Arimidex. Since Cytadren is not currently being counterfeited, all preparations seen on the black market could be considered a safe buy. Although Cytadren manufactured in the United States, the black market will generally carry the Orimeten brand name from Europe.
Although many believe they have used Cytadren as such, few ever reach the discussed necessary four Cytadren tablets day to notice true cortisol suppression. Cytadren is very rarely used as an anti-catabolic in a correct manner, those who do venture this high commonly report fatigue and discomfort, stating that Cytadren is intolerable for type of prolonged use. Sadly, we are starting to realize that its original proposed use of Cytadren as a n steroidal muscle-building agent does not seem a plausible one. The only instances I really have heard of Cytadren ever being used at such doses with any type of positive response were competitive bodybuilders partaking in hic dosed Cytadren shortly before a show. They claimed the short-term rise in androgen to corticosteroid ratio grea aided in their abilities to bring out a show-ready hard and dense physique, and credit the drug as genuinely being very effective pre-contest agent. In speaking with the late Paul Borresen he summed up the pre-contest use Cytadren nicely: "I have had considerable experience with the high dose use. It makes athletes sleepy and weak. It seems to help the last t6 days before a show, and this is tried and tested."
